p30: are there anxious genes?

نویسندگان

leyla bayan shefa neuroscience research center, khatam alanbia hospital, tehran, iran

arezou eshaghabadi shefa neuroscience research center, khatam alanbia hospital, tehran, iran

چکیده

anxiety comprises many clinical descriptions and phenotypes. a genetic predisposition to anxiety is undoubted; however, the nature and extent of that contribution is still unclear. extensive genetic studies of the serotonin (5-hydroxytryptamine, 5-ht) transporter (5-htt) gene have revealed how variation in gene expression can be correlated with anxiety phenotypes. complete genome-wide linkage scans for panic disorder (pd) susceptibility genes have suggested a locus on chromosome arm 7p, and association studies have highlighted many candidate genes. a genetic contribution to psychological traits and psychiatric disorders is not in doubt, but the nature and extent of that contribution is still unclear. genetic epidemiology has assembled convincing evidence that anxiety and related disorders are influenced by genetic factors and that the genetic component is highly complex. while studies of the patterns of inheritance of personality indicate that various dimensions are likely to be influenced by many genes and quantitative traits, it also documents the significance of environmental factors. as the modes of inheritance of anxiety disorders are complex, it has been concluded that multiple genes of small effect, in interaction with each other and with nongenetic neurodevelopmental events, produce vulnerability to the disorder. the interest for gene– environment interactions in the study of anxiety is still in its infancy on the background of the nature/nurture debate. both human and animal studies thus far support the genetic complexity of anxiety. clinical manifestations of these diseases are likely to be related to multiple genes, of which some may modify or influence the expression of the disease. in order to solve the complex problem of anxiety, the full array of genetic strategies will be needed. we conclude that anxiety is a complex behaviour, underlined not only by genetic or environmental factors but also by multiple interactions between these two factors.

برای دانلود باید عضویت طلایی داشته باشید

برای دانلود متن کامل این مقاله و بیش از 32 میلیون مقاله دیگر ابتدا ثبت نام کنید

اگر عضو سایت هستید لطفا وارد حساب کاربری خود شوید

منابع مشابه

P30: Are There Anxious Genes?

Anxiety comprises many clinical descriptions and phenotypes. A genetic predisposition to anxiety is undoubted; however, the nature and extent of that contribution is still unclear. Extensive genetic studies of the serotonin (5-hydroxytryptamine, 5-HT) transporter (5-HTT) gene have revealed how variation in gene expression can be correlated with anxiety phenotypes. Complete genome-wide linkage s...

متن کامل

Are there anxious genes?

Anxiety comprises many clinical descriptions and phenotypes. A genetic predisposition to anxiety is undoubted; however, the nature and extent of that contribution is still unclear. Methods for the genetic analysis of such complex disorders is briefly reviewed, followed by a discussion of the comorbidity of anxiety with other psychiatric disorders and their possible common genetic etiology. Exte...

متن کامل

SnoPatrol: how many snoRNA genes are there?

Small nucleolar RNAs (snoRNAs) are among the most evolutionarily ancient classes of small RNA. Two experimental screens published in BMC Genomics expand the eukaryotic snoRNA catalog, but many more snoRNAs remain to be found.

متن کامل

How many genes are there in plants (... and why are they there)?

Annotation of the first few complete plant genomes has revealed that plants have many genes. For Arabidopsis, over 26,500 gene loci have been predicted, whereas for rice, the number adds up to 41,000. Recent analysis of the poplar genome suggests more than 45,000 genes, and partial sequence data from Medicago and Lotus also suggest that these plants contain more than 40,000 genes. Nevertheless,...

متن کامل

Why are there still over 1000 uncharacterized yeast genes?

The yeast genetics community has embraced genomic biology, and there is a general understanding that obtaining a full encyclopedia of functions of the approximately 6000 genes is a worthwhile goal. The yeast literature comprises over 40,000 research papers, and the number of yeast researchers exceeds the number of genes. There are mutated and tagged alleles for virtually every gene, and hundred...

متن کامل

Gene number. What if there are only 30,000 human genes?

The confirmation that there might be fewer than 30,000 protein-coding genes in the human genome is one of the key results of the monumental work presented in this issue of Science by Venter et al. (1). That a mere one-third increase in gene numbers could be enough to progress from a rather unsophisticated nematode [Caenorhabditis elegans, with about 20,000 genes (2)] to humans (and other mammal...

متن کامل

منابع من

با ذخیره ی این منبع در منابع من، دسترسی به آن را برای استفاده های بعدی آسان تر کنید


عنوان ژورنال:
مجله علوم اعصاب شفای خاتم

جلد ۴، شماره ۳، صفحات ۵۳-۵۳

کلمات کلیدی

میزبانی شده توسط پلتفرم ابری doprax.com

copyright © 2015-2023